engineering services
Process Engineering
Get the most from your bioprocessing platforms
Our team of experienced engineers provides process solutions that include conceptual design, as well as support with process scale-up through to large-scale commercial manufacturing. Our keen understanding of business systems enables AES to offer process solutions that support your data collection and management needs and seamless integration with your critical business systems. AES delivers solutions designed to help you get the most from your bioprocessing platforms and to run your facility at its full potential.
Specific process engineering services include:
- Conceptual design
- Equipment/control
- Process via Run Manager or Batch Executive
- Implementation: install, startup, validation, training, maintenance
- Systems integration
– Clean-in-place (CIP) system integration
– Steam-in-place (SIP) execution - Business systems integration: LIMS, ERP, MES and other critical business systems
System benefits
The system creates the ideal environment for a wide range of cell lines and organisms and supports high cell density processes. Typical applications include bacterial and mammalian product cell line systems. Bioreactors, available in sizes from 2L to XXL, can be used as a platform for solera, seed train, perfusion or N stage batch and fed-batch operations. bioreactor system
Space-saving design that’s easy to use
The system’s streamlined externally housed quad-pump saves you valuable work space whether in the lab or a commercial environment. And when part of an automated process, the industrial control layer enables remote process monitoring and control wherever network access is available. The control system’s intuitive user interface makes it easy for you to monitor and adjust all processes running on the AES Bioreactor Cell Culture System.
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YOU keep control
The control layer creates a modular system that easily integrates with an existing distributed control system (DCS) or as the start of a new site DCS. All online adjustments, historization and system information is presented remotely through your networked computer or local HMI. Control hardware and software are 21 CFR Part 11, GMP/GLP and ISA-88 compliant to satisfy regulatory requirements. Additionally, all control software code is transparent and open source, giving you the freedom to make modifications as needed. will also provide continued support, as needed, ervice
Technical Specifications
| Size (W x H x D) | ??? |
| Voltage/Amperage | ??? |
Vessel
| Total volume | 2100 mL |
| Working volume | 1800 mL |
| Internal diameter (glass reactor) | 105 mm |
| Overall height (glass reactor) | 246 mm |
Control
| DCS | Emerson DeltaV, DeltaV Discovery, PK Controller or Rockwell PlantPAX |
| Hardware protocol | Ethernet/IP, DeviceNet, Profibus (others available upon request) |
| Interface | Windows®-based PC or HMI |
| Software standard | ISA-88.1 |
Process Instrumentation
| Heat control | Single-sided, heating blanket |
| pH control | Mettler Toledo |
| DO control | Polarographic or Optical Mettler Toledo |
| Pump control | 3x integrated pumps for additions and harvest, Master Flex |
| Gas control | 3x MFCs |
| Temperature probe | PT100 RTD |
| Heat source | Relay controlled heating jacket |
| O2 | Brooks 2000 sccm |
| Mixed Air | Brooks 2000 sccm |
| CO2 | Brooks 2000 sccm |
| N2 | Brooks 2000 sccm *additional cost applies |
| Agitation | Direct Drive, 10-800 RPM |
Specifications subject to change without notice.