engineering services
Instrumentation and Hardware Solutions
We’ll help you optimize your process through efficient and reliable instrumentation that meets your needs today and in the future.
AES provides instrumentation and hardware solutions from specification to design and installation, across both upstream and downstream workflows. If our standard equipment configurations do not meet your exact needs, our team of engineers will custom design and fabricate a solution that matches your requirements.
All installation, testing and qualification with software is conducted by process and equipment engineers. Our engineering team will also provide support during the initial stages of post-release use, ensuring a seamless transition and comprehensive training on your new instrumentation and other hardware. We also provide customized options for different levels of testing and associated documentation packages (e.g., I/OQ,PQ), depending on our requirements.
Count on AES from start to finish: Instrument and hardware specification, commissioning, design/fabrication of customized hardware, installation, qualification, training and support for as long as you need it.
Specific instrumentation and hardware solutions include:
- Specification of instrumentation/equipment and compatible consumables, commissioning, design/fabrication
– Bioreactor cell culture systems
– Rocker cell expansion systems
– Chromatography skids
– Centrifugation apparatus
– Filtration
– Media/buffer vessels
– Compatible consumables - Custom cabinets
– For clean rooms or uncontrolled spaces
– Large and small footprints
System benefits
The system creates the ideal environment for a wide range of cell lines and organisms and supports high cell density processes. Typical applications include bacterial and mammalian product cell line systems. Bioreactors, available in sizes from 2L to XXL, can be used as a platform for solera, seed train, perfusion or N stage batch and fed-batch operations. bioreactor system
Space-saving design that’s easy to use
The system’s streamlined externally housed quad-pump saves you valuable work space whether in the lab or a commercial environment. And when part of an automated process, the industrial control layer enables remote process monitoring and control wherever network access is available. The control system’s intuitive user interface makes it easy for you to monitor and adjust all processes running on the AES Bioreactor Cell Culture System.
Caption for control panel image
Caption for screenshot to go here
YOU keep control
The control layer creates a modular system that easily integrates with an existing distributed control system (DCS) or as the start of a new site DCS. All online adjustments, historization and system information is presented remotely through your networked computer or local HMI. Control hardware and software are 21 CFR Part 11, GMP/GLP and ISA-88 compliant to satisfy regulatory requirements. Additionally, all control software code is transparent and open source, giving you the freedom to make modifications as needed. will also provide continued support, as needed, ervice
Technical Specifications
| Size (W x H x D) | ??? |
| Voltage/Amperage | ??? |
Vessel
| Total volume | 2100 mL |
| Working volume | 1800 mL |
| Internal diameter (glass reactor) | 105 mm |
| Overall height (glass reactor) | 246 mm |
Control
| DCS | Emerson DeltaV, DeltaV Discovery, PK Controller or Rockwell PlantPAX |
| Hardware protocol | Ethernet/IP, DeviceNet, Profibus (others available upon request) |
| Interface | Windows®-based PC or HMI |
| Software standard | ISA-88.1 |
Process Instrumentation
| Heat control | Single-sided, heating blanket |
| pH control | Mettler Toledo |
| DO control | Polarographic or Optical Mettler Toledo |
| Pump control | 3x integrated pumps for additions and harvest, Master Flex |
| Gas control | 3x MFCs |
| Temperature probe | PT100 RTD |
| Heat source | Relay controlled heating jacket |
| O2 | Brooks 2000 sccm |
| Mixed Air | Brooks 2000 sccm |
| CO2 | Brooks 2000 sccm |
| N2 | Brooks 2000 sccm *additional cost applies |
| Agitation | Direct Drive, 10-800 RPM |
Specifications subject to change without notice.